Hello Deepak
yes it is possible to apply for skilled visas from Nepal. If you have the necessary skills and experiences, please visit one of the migration agents in Nepal and they will be able to provide you with right advice on this.
Also, please watch this video:
Can I Come to Australia on a Work Visa from Nepal?
https://youtu.be/Cpo5bgyyFZw
best wishes
Lakshman Basnet Selected answer as best April 2, 2023